Vitamin C with Niacinamide: Friend or Foe for the skin?

Vitamin C with Niacinamide: Friend or Foe for the skin?

Vitamin C is by far one of the best and most favorite ingredients for a youthful and glowing skin. After vitamin C, niacinamide has sprung up as an “elixir” in skin care products.In the pursuit of healthy skin, it is inevitable to feel enticed to reap the benefits of both ingredients for your skin.

However, the information available on the internet has mixed reviews about pairing Vitamin C And Niacinamide. Some say that combining these ingredients can help to up your skin care game while others say opposite to it that this combo may break down your skin care goals. 

We really understand that it becomes tough to conclude whether you should try this super duo for your skin or not.

Well, take a breather, we are here to help you find the clarity of skin ingredients so that you can have a clear skin of your dreams.

It is imperative to understand that not all, but only a few vitamin C derivatives can be formulated with Niacinamide and serves a skin perfecting combo. 

This is why - Back in the 1960s, a research study showed the incompatibility between niacinamide and vitamin C. In the experiment, non-stabilized forms of both the ingredients were used which resulted in adverse skin reactions. The great news is that modern skin care formulas utilize stable forms of both ingredients to get maximum results with negligible side effects.

Before pairing niacinamide and vitamin C together, you need to know which combination is well suitable for your unique skin type and concern
  • Ethyl Ascorbic Acid with Niacinamide 
  • Sodium Ascorbyl phosphate with Niacinamide 
  • L Ascorbic acid with Niacinamide 
  • Ascorbyl glucoside with Niacinamide
1. Ethyl Ascorbic Acid with Niacinamide 

Reportedly, Ethyl Ascorbic Acid with Niacinamide is not a recommended combination in skin care.

Different pH values of both ingredients is the real problem . Since pH is one of the most important things that affects the stability of products.

Niacinamide performs best at around a neutral pH of 6-7. On the other hand, Ethyl Ascorbic Acid has pH of less than or equal to 3.

When these two ingredients are manufactured together they form a by-product called nicotinic acid . Nicotinic acid is an impurity that may increase the risk of purging, redness, and skin irritation.

When used separately both niacinamide and ethyl ascorbic acid offer many dermatological advantages for your skin.

Ethyl ascorbic acid-based serums target skin problems like hyperpigmentation, blemishes, fine lines, wrinkles and dull complexion . This vitamin C derivative is found suitable only for normal skin types, not sensitive skin and acne prone skin types. 

You can use Ethyl Ascorbic Acid (EAA) serums in your morning skin care routine for strong antioxidant protection throughout the day and niacinamide serums at night for improved skin barrier functions and skin rejuvenation.

2. Sodium Ascorbyl phosphate with Niacinamide

For acne prone skin types, Sodium Ascorbyl Phosphate (SAP) with Niacinamide is a powerful combination.

Sodium Ascorbyl phosphate is a stable, water soluble derivative of vitamin C which does not oxidize easily. Similarly, niacinamide is a stable compound.

Additionally, Sodium Ascorbyl Phosphate pH value lies between 7-8 which is very near to niacinamide pH value.  

When ingredients are combined together, they can fix many problems of  oily/ acne prone skin. Their antioxidants, anti-inflammatory, antiaging, and sebum regulating properties that speed up the acne healing process and offer clear, smooth, and radiant skin.



3.  L Ascorbic acid with Niacinamide

Pairing L Ascorbic acid with Niacinamide is not considered an effective combination and may cause adverse skin reactions.

Backed by science studies, both the ingredients in single skin care formulation become unstable and lose their efficacy to show desired results.

It's best to avoid using these ingredients at the same time, make sure to wait for 25-30 minutes during each application.

4. Ascorbyl glucoside with Niacinamide

The answer is yes. In theoretical studies, teaming up Ascorbyl glucoside with Niacinamide is regarded as safe and effective.

However, there are very limited clinical trials in dermatology that support the efficacy of this combination for skin.

Final takeaway

In nutshell, Niacinamide and vitamin C work wonders for your skin. Putting both ingredients in your skin care regimen can benefit your skin in multiple ways. Vitamin C helps to get rid of pigmentation and dark spots by inhibiting the activity of tyrosinase, an enzyme responsible for the overproduction of melanin. Whereas, niacinamide helps to improve skin barrier functions, restores the natural glow of skin, heals acne, and refines skin texture.


Vitamin C and niacinamides can be easily incorporated into skin care routine. The easiest and convenient option is to find a single product that consists of both ingredients. But, again it is important to understand your skin care needs before switching to any skin care product. 

Also, you can use niacinamide and vitamin C individually. If you are planning to use vitamin C in your morning skin care routine, you can layer niacinamide in your night skin care regimen.

Re’equil face serums are formulated for all skin types that cater to both your basic skin needs and complicated skin concerns. 



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